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Neue Version der S3-Leitlinie zum Melanom veröffentlicht

Heute wurde die aktuelle Version der S3-Leitlinie zum malignen Melanom auf den Seiten des Leitlinienprogramms Onkologie der DKG veröffentlicht.

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Aktuelle Ausschreibungen der Hiege-Stiftung gegen Hautkrebs - 2018

Gerne machen wir auf die diesjährigen Ausschreibungen der Hiege-Stiftung gegen Hautkrebs aufmerksam. Die Details finden Sie in den beiliegenden PDF-Dokumenten.

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NUB-Anträge 2017/8 verfügbar

Die aktuellen Template für die NUB-Anträge 2017/8 sind online.

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Präsentation der Studiensitzung verfügbar

Die Folien mussten leider von der Seite entfernt werden.

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Hautkrebskongress 2017: Neue Erkenntnisse und aktuelle Therapiemöglichkeiten in der Dermato-Onkologie

Beim 27. Deutschen Hautkrebskongress der ADO und der Deutschen Dermatologischen Gesellschaft, der vom 21. - 23. September 2017 in Mainz stattfindet, werden vielversprechende aktuelle Erkenntnisse und Forschungsergebnisse in Prävention, Diagnostik und Therapie in der Dermato-Onkologie vorgestellt und von internationalen Experten diskutiert.

Nicht nur in der Therapie des fortgeschrittenen Melanoms, des Basalzellkarzinoms und in der Behandlung aktinischer Keratosen, auch bei anderen Hautkrebsarten gibt es hoffnungsvolle Fortschritte. Herr Prof. Stephan Grabbe und Frau PD Dr. med. Carmen Loquai geben Einblick in Highlights des Kongresses.

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PubMed – Neue Publikationen

Baseline neutrophil-to-lymphocyte ratio (NLR) and derived NLR could predict overall survival in patients with advanced melanoma treated with nivolumab.

Related Articles

Baseline neutrophil-to-lymphocyte ratio (NLR) and derived NLR could predict overall survival in patients with advanced melanoma treated with nivolumab.

J Immunother Cancer. 2018 Jul 16;6(1):74

Authors: Capone M, Giannarelli D, Mallardo D, Madonna G, Festino L, Grimaldi AM, Vanella V, Simeone E, Paone M, Palmieri G, Cavalcanti E, Caracò C, Ascierto PA

Abstract
BACKGROUND: Previous studies have suggested that elevated neutrophil-to-lymphocyte ratio (NLR) is prognostic for worse outcomes in patients with a variety of solid cancers, including those treated with immune checkpoint inhibitors.
METHODS: This was a retrospective analysis of 97 consecutive patients with stage IV melanoma who were treated with nivolumab. Baseline NLR and derived (d) NLR were calculated and, along with other characteristics, correlated with progression-free survival (PFS) and overall survival (OS) in univariate and multivariate analyses. The best cutoff values for NLR and dNLR were derived using Cutoff Finder software based on an R routine which optimized the significance of the split between Kaplan-Meier survival curves.
RESULTS: In univariate analysis, increasing absolute neutrophil count (ANC), NLR, dNLR and lactate dehydrogenase (LDH) (continuous variables) were all significantly associated with OS. Only NLR (hazard ratio [HR] = 2.85; 95% CI 1.60-5.08; p < 0.0001) and LDH (HR = 2.51; 95% CI 1.36-4.64; p < 0.0001) maintained a significant association with OS in multivariate analysis. Patients with baseline NLR ≥5 had significantly worse OS and PFS than patients with NLR < 5, as did patients with baseline dNLR ≥3 versus < 3. Optimal cut-off values were ≥ 4.7 for NLR and ≥ 3.8 for dNLR. Using this ≥4.7 cut-off for NLR, the values for OS and PFS were overlapping to the canonical cut-off for values, and dNLR< 3.8 was also associated with better OS and PFS.
CONCLUSION: Both Neutrophil-to-lymphocyte ratio (NLR) and derived (d) NLR were associated with improved survival when baseline levels were lower than cut-off values. NLR and dNLR are simple, inexpensive and readily available biomarkers that could be used to help predict response to immunotherapy in patients with advanced melanoma.

PMID: 30012216 [PubMed - in process]

The Role of Sunscreen in the Prevention of Cutaneous Melanoma and Non-Melanoma Skin Cancer.

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The Role of Sunscreen in the Prevention of Cutaneous Melanoma and Non-Melanoma Skin Cancer.

J Am Acad Dermatol. 2018 Jul 13;:

Authors: Waldman RA, Grant-Kels JM

PMID: 30012373 [PubMed - as supplied by publisher]

Severe hemophagocytic lymphohistiocytosis in a melanoma patient treated with ipilimumab + nivolumab.

Related Articles

Severe hemophagocytic lymphohistiocytosis in a melanoma patient treated with ipilimumab + nivolumab.

J Immunother Cancer. 2018 Jul 16;6(1):73

Authors: Hantel A, Gabster B, Cheng JX, Golomb H, Gajewski TF

Abstract
BACKGROUND: Treatment of metastatic melanoma patients with immune checkpoint inhibitors is an important standard of care. Side effects are due to immune activation, can affect virtually all organ systems, and are occasionally severe. Although hematologic toxicity has been reported, we present a case of hemophagocytic lymphohistiocytosis (HLH) due to immune checkpoint inhibitor therapy.
CASE PRESENTATION: A patient with metastatic melanoma was treated with one course of ipilimumab + nivolumab and presented 3 weeks later with severe anemia and hyperferritinemia. A bone marrow biopsy revealed necrotic tumor cells, infiltrating T cells, and hemophagocytosis. The patient was treated with high-dose steroids; 12 months later, the patient remains off all therapy and in complete remission of both HLH and metastatic melanoma.
CONCLUSIONS: The hemophagocytic syndromes are attributable to dysregulated immune activation and share pathophysiologic mechanisms with immune activation from checkpoint inhibitors. Increasing use of regimens that include immune checkpoint inhibition require vigilant monitoring for immune-activating side effects as they can occasionally be life threatening, as in this case of HLH.

PMID: 30012206 [PubMed - in process]

PDQ Cancer Information Summaries

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PDQ Cancer Information Summaries

Book. 2002

Authors:

Abstract
This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the treatment of intraocular melanoma. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions. This summary is reviewed regularly and updated as necessary by the PDQ Adult Treatment Editorial Board, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH).


PMID: 26389482

PDQ Cancer Information Summaries

Related Articles

PDQ Cancer Information Summaries

Book. 2002

Authors:

Abstract
This PDQ cancer information summary has current information about the treatment of intraocular melanoma. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care. Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when there is new information. The date on each summary ("Date Last Modified") is the date of the most recent change. The information in this patient summary was taken from the health professional version, which is reviewed regularly and updated as needed, by the PDQ Adult Treatment Editorial Board.


PMID: 26389277

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